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Abnova/AKT1 (phospho S129) polyclonal antibody/1kit/PAB2612
  • Abnova/AKT1 (phospho S129) polyclonal antibody/1kit/PAB2612

Abnova/AKT1 (phospho S129) polyclonal antibody/1kit/PAB2612

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貨號: PAB2612
品牌: Abnova
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  • 詳情
  • 使用說明
  • 常見問題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
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      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1.
      • Immunogen:
      • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S129 of human AKT1.
      • Host:
      • Rabbit
      • Reactivity:
      • Human
      • Form:
      • Liquid
      • Purification:
      • Protein A purification
      • Recommend Usage:
      • Dot Blot (1:~500)ELISAThe optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS (0.09% sodium azide)
      • Storage Instruction:
      • Store at 4°C for up to 2 weeks. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Publication Reference
      • 1.
      • Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway.DeBusk LM, Hallahan DE, Lin PC.Exp Cell Res. 2004 Aug 1;298(1):167-77.
      • 2.
      • EGF-dependent cell cycle progression is controlled by density-dependent regulation of Akt activation.LeVea CM, Reeder JE, Mooney RA.Exp Cell Res. 2004 Jul 1;297(1):272-84.
      • 3.
      • Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT.Kyoung Pyo H, Lovati E, Pasinetti GM, Ksiezak-Reding H.Neuroscience. 2004;127(3):649-58.
      • Applications
      • Enzyme-linked Immunoabsorbent Assay
      • Dot Blot (Peptide)
      • Dot Blot (Peptide)
      • Dot blot analysis of AKT1 (phospho S129) polyclonal antibody (Cat # PAB2612) on nitrocellulose membrane. 50 ng of phospho-peptide or non phospho-peptide per dot were adsorbed.
      • Application Image
      • Enzyme-linked Immunoabsorbent Assay
      • Dot Blot (Peptide)
      • Dot Blot (Peptide)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 207
      • Protein Accession#:
      • NP_005154; P31749
      • Gene Name:
      • AKT1
      • Gene Alias:
      • AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA
      • Gene Description:
      • v-akt murine thymoma viral oncogene homolog 1
      • Omim ID:
      • 164730, 181500
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
      • Other Designations:
      • RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase alpha
      • Interactome
      • Interactome
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      • Fc gamma R-mediated phagocytosis
      • Focal adhesion
      • Glioma
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      • Jak-STAT signaling pathway
      • MAPK signaling pathway
      • Melanoma
      • mTOR signaling pathway
      • Neurotrophin signaling pathway
      • Non-small cell lung cancer
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      • Pathways in cancer
      • Prostate cancer
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      • Small cell lung cancer
      • T cell receptor signaling pathway
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      • Toll-like receptor signaling pathway
      • VEGF signaling pathway
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      • Carcinoma, Papillary
      • Carcinoma, Papillary, Follicular
      • Cardiovascular Diseases
      • Cognition
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      • Coronary Artery Disease
          • ... see more
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