Properties:
RelatedCategories | BloodandUrineChemistryAssayKits,CellBIOLOGy,EnzymaticActivityAssayKits,EnzymaticKitsfortheQuantitationofNutrientsandMetabolites,MetabolismAssayKitsA-Z, |
storagetemp. | −20°C |
Description:
Generaldescription
ThecoagulationFactorVIII,alsoknownasanti-hemophilicfactor(AHF)isavitalblood-clottingprotein.FactorVIIIcirculatesinthebloodstreamasaninactiveprotein,boundtoalargemultimericglycoproteincalledvonWillebrandfactor(VWF).Uponaninjurytothebloodvessel,VWFdissociatesfromFVIIIandreleasestheactiveformofFVIII(FVIIIa).Inthepresenceofcalciumionsandnegativelychargedmembranephospholipids,activatedfactorVIII(FVIIIa)thenbindstotheactivatedFactorIX(FIXa)andproteolyticallyactivatesfactorX(FX)tofactorXa(FXa).
SuitABIlity
SuitableforthedeterminationofFactorVIIIactivityinserumandplasmasamples