Properties:
RelatedCategories | BloodandUrineChemistryAssayKits,CellBIOLOGy,EnzymaticKitsfortheQuantitationofNutrientsandMetabolites,GlycolysisMetabolismAssayKits,Metabolomics |
Description:
Generaldescription
D-Lactate,typicallypresentinthebloodstreamatnanomolarconcentrations,isproducedbyanintestinalsourceorviathemethylglyoxalpathway.Inmammals,D-LactatemetabolismrequiresD-Lactatehydrogenaseandismetabolizedslowly,thusanincreaseinbloodconcentrationlevelscanleadtoacidemiaandacidosis.TheseverityofthisD-lacticacidosiscanbeassociatedwithneurotoxicsymptoms.SignificantD-Lactateaccumulationsinthebodycanalsoberelatedtoimpairedmetabolismandexcretion.
Inthisassay,D-LactateisspecificallyoxidizedbyD-Lactatehydrogenaseandgeneratesaproportionalcolorimetricproductmeasuredat450nm.Theusefulconcentrationrangeinsamplesis0.1-10mMD-Lactate.
SuitABIlity
Suitableforusewithsamplesofserum,plasma,cells,cultureandfermentationmedia.
Safety:
Symbol
GHS05
Hazardstatements
H318-H412
Precautionarystatements
P273-P280-P305+P351+P338
RIDADR
NONHforallmodesoftransport