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Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL
  • Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL

Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL

價(jià)格: ￥3948.00 市場價(jià): 6580.00
貨號: MABS77
品牌: Millipore
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    • Description
      CatalogueNumberMABS77
      Replaces04-361
      DescriptionAnti-GSK-3alpha/betaAntibody,clone12B11.1
      AlternateNames
      • Glycogensynthasekinase-3alpha
      • GSK-3alpha
      • Serine/threonine-proteinkinaseGSK3A
      BackgroundInformationGlycogensynthase-3alpha(GSK-3alpha)isaubiquitousconstitutively-activemultifunctionalkinase.GSK-3alphaphosphorylatesserineandthreonineresiduesonitstargetsubstrates,mostofwhichare“primed”orprephosphorylated.ItismostwidelyresearchedforitsinteractionwithglycogensynthasewhichisdeactivatedafterphosphorylationbyGSK-3alpha;thisactivityblocksthesynthesisofglycogenandplaysanimportantroleintheregulationofglycogen.GSK-3alphaisalsoinvolvedintheWnt/β-catenin,Notch,andHedgehogsignalingpathwaysandaffectsawiderangeofcellularprocessesincludingcell-cycleregulation,transcription,andapoptosis.GSK-3alphaalsophosphorylatestauproteinsandmaycontributetothegenerationofAPP-derivedamyloidplaqueswhichareinvolvedinthepathogenesisofAlzheimer’sdisease.GSK-3alphaisalsoinvestigatedforitsroleintype2diabetes,andcancer.
      ProductInformation
      FormatPurified
      Control
      • Jurkatcelllysate
      PresentationPurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationThisAnti-GSK-3alpha/betaAntibody,clone12B11.1isvalidatedforuseinWesternBlotting,ICCforthedetectionofGSK-3alpha/beta.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      ApplicationNotesImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedGSK-3alpha/betainHeLaandA431cells.
      BIOLOGicalInformation
      ImmunogenOvalbumin-conjugatedlinearpeptidecorrespondingtohumanGSK-3alpha/beta.
      Clone12B11.1
      HostMouse
      IsotypeIgMκ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamultifunctionalSer/Thrproteinkinasethatisimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase,andtranscriptionfactors,suchasJUN.ItalsoplaysaroleintheWNTandPI3Ksignalingpathways,aswellasregulatestheproductionofbeta-amyloidpeptidesassociatedwithAlzheimer"sdisease.[providedbyRefSeq,Oct2011].
      GeneSymbol
      • GSK3A
      • GSK-3alpha/beta
      PurificationMethodPurifiedbyIon-ExchangeChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:Constitutivelyactiveproteinkinasethatactsasanegativeregulatorinthehormonalcontrolofglucosehomeostasis,Wntsignalingandregulationoftransctiptionfactorsandmicrotubules,byphosphorylatingandinactivatingglycogensynthase(GYS1orGYS2),CTNNB1/beta-catenin,APCandAXIN1.Requiresprimedphosphorylationofthemajorityofitssubstrates.ContributestoinsulinregulationofglycogensynthesisbyphosphorylatingandinhibitingGYS1activityandhenceglycogensynthesis.Regulatesglycogenmetabolisminliver,butnotinmuscle.Mayalsomediatethedevelopmentofinsulinresistancebyregulatingactivationoftranscriptionfactors.InWntsignaling,regulatesthelevelandtranscriptionalactivityofnuclearCTNNB1/beta-catenin.Facilitatesamyloidprecursorprotein(APP)processingandthegenerationofAPP-derivedamyloidplaquesfoundinAlzheimerdisease.Maybeinvolvedintheregulationofreplicationinpancreaticbeta-cells.Isnecessaryfortheestablishmentofneuronalpolarityandaxonoutgrowth.

      CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate.

      ATP+aprotein=ADP+aphosphoprotein.

      ENZYMEREGULATION:ActivatedbyphosphorylationatTyr-279.Inresponsetoinsulin,inhibitedbyphosphorylationatSer-21byPKB/AKT1;phosphorylationatthissitecausesaconformationalchange,preventingaccessofsubstratestotheactivesite.Inhibitedbylithium.

      SUBUNITSTRUCTURE:Monomer.InteractswithARRB2(Bysimilarity).InteractswithAXIN1andCTNNB1/beta-catenin.

      PTM:PhosphorylatedbyAKT1atSer-21:uponinsulin-mediatedsignaling,theactivatedPKB/AKT1proteinkinasephosphorylatesanddesactivatesGSK3A,resultinginthedephosphorylationandactivationofGYS1.ActivatedbyphosphorylationatTyr-279.

      MISCELLANEOUS:HigherexpressionandactivityofGSK3Aarefoundintheskeletalmuscle(vastuslateralis)ofpatientswithtype2diabetes(Ref.5).SeveralpotentGSK3(GSK3AandGSK3B)inhibitorshavebeenidentifiedandcharacterizedinpreclinicalmodelsfortreatmentsoftype2diabetes(Ref.17).

      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.

      Contains1proteinkinasedomain.
      MolecularWeight~46/51kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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