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Millipore/MABS50 | Anti-Cdk5 Antibody, clone 1H3/MABS50/100 µg
  • Millipore/MABS50 | Anti-Cdk5 Antibody, clone 1H3/MABS50/100 µg

Millipore/MABS50 | Anti-Cdk5 Antibody, clone 1H3/MABS50/100 µg

價格: ¥3324.00 市場價: 5540.00

貨號: MABS50
品牌: Millipore
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    • Description
      CatalogueNumberMABS50
      DescriptionAnti-Cdk5Antibody,clone1H3
      AlternateNames
      • cyclin-dependentkinase5
      • TauproteinkinaseIIcatalyticsubunit
      • Serine/threonine-proteinkinasePSSALRE
      • proteinkinaseCDK5splicing
      • TPKIIcatalyticsubunit
      BackgroundInformationCyclin-dependentkinase5(CDK5),belongstothecyclin-dependentkinasefamily.Itismostactiveinthecentralnervoussystemandplaysanimportantroleintheregulationofcytoskeletalfunction.CDK5expressionhasbeenobservedintestis,kidney,andovarywithhigherlevelsseeninpostmitoticneuronsindevelopingandadultnervoussystems.MutationsinCDK5havebeenassociatedwithAlzheimer"sdisease,Parkinson"sdisease,andALS,suggestingthatCDK5mayplayakeyroleinseveralneurodegenerativedisorders.
      ProductInformation
      FormatPurified
      Control
      • HeLacelllysate
      PresentationPurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-Cdk5Antibody,clone1H3detectslevelofCdk5&hasbeenpublished&validatedforuseinWB,IC,IH.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry
      ApplicationNotesImmunocytochemistryAnalysis:ThisantibodyhasbeenshowntodetectCDK5inmousebrainhistologicalsections.(Legace,D.C.,etal.(2008).ProcNatlAcadSciUSA.105:18567-18571.)
      BIOLOGicalInformation
      ImmunogenHumanCDK5crosslinkedtohomogenizedsurgicalsuturematerial
      Clone1H3
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesCDK5.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhuman.Predictedtoreactwithmouseandratbasedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • CDK5
      • PSSALRE
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Probablyinvolvedinthecontrolofthecellcycle.InteractswithD1andD3-typeG1cyclins.CanphosphorylatehistoneH1,tau,MAP2andNF-HandNF-M.Alsointeractswithp35whichactivatesthekinase.

      SIZE:292aminoacids;33304Da

      SUBUNIT:Heterodimerofacatalyticsubunitandaregulatorysubunit(p35).FoundinatrimolecularcomplexwithCABLES1andABL1.InteractswithCABLES1(Bysimilarity).InteractswithAATK.

      SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Cellprojection,growthcone(Bysimilarity).Note=Inaxonalgrowthconewithextensiontotheperipherallamellipodia(Bysimilarity).

      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.CDC2/CDKXsubfamily.&Contains1proteinkinasedomain....hide?seemore?
      MolecularWeight33kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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