BackgroundInformation | Cyclin-dependentkinase5(CDK5),belongstothecyclin-dependentkinasefamily.Itismostactiveinthecentralnervoussystemandplaysanimportantroleintheregulationofcytoskeletalfunction.CDK5expressionhasbeenobservedintestis,kidney,andovarywithhigherlevelsseeninpostmitoticneuronsindevelopingandadultnervoussystems.MutationsinCDK5havebeenassociatedwithAlzheimer"sdisease,Parkinson"sdisease,andALS,suggestingthatCDK5mayplayakeyroleinseveralneurodegenerativedisorders. |