Immunogen | AffinitypurifiedextracellulardomainofhumanK-cadherin |
Epitope | extracellulardomain |
Clone | 2B6 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | ReactswiththeextracellulardomainofK-cadherin. |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneencodesatypeIIclassicalcadherinfromthecadherinsuperfamily.Theencodedmembraneproteinisacalciumdependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Cadherinsmediatecell-cellbindinginahomophilicmanner,contributingtothesortingofheterogeneouscelltypesandthemaintenanceoforderlystructuressuchasepithelium.Strongtranscriptionalexpressionofthisgenehasbeenobservedinhepatocellularandrenalcarcinomacelllines,suggestingapossibleroleinmetastasisandinvasion. |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P55285#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes. SIZE:790aminoacids;88309Da SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Highlyexpressedinbrain,cerebellum,andkidney.Lung,pancreas,andgastricmucosashowaweakexpression.Alsoexpressedincertainliverandkidneycarcinomas. SIMILARITY:SwissProt:P55285##Contains5cadherindomains. |