Immunogen | TyrosineHydroxylasepurifiedfromPC12cells. |
Epitope | RecognizesanepitopeontheoutsideoftheregulatoryN-terminusoftyrosinehydroxylase. |
Clone | LNC1 |
Host | Mouse |
Specificity | TyrosineHydroxylase.Recognizesaproteinofapproximately59-63kDabyWesternblot.DoesnotreactwiththefollowingonWesternBlots:dopamine-beta-hydroxylase,phenylalaninehydroxylase,trytophanhydroxylase,dehydropteridinereductase,sepiapterinreductase,phenethanolamine-N-methyltransferase(PNMT). |
Isotype | IgG1κ |
SpeciesReactivity | - Chicken
- Human
- Mouse
- Monkey
- Rat
- Frog
- Lizard
- Vole
- Zebrafish
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |