Usp5 (IsoT) is a deubiquitinase enzyme that hydrolyzes free polyubiquitin chains.The Usp5 contains two zinc finger domains (ZnF-UBP).This product contains the second ZnF-UBP domain (amino acid 163 – 291).The ZnF-UBP domains bind free ubiquitin chains’ diglycine carboxyl tail, which defines its specificity in binding of free polyubiquitin chains.