Immunogen | 35residuesyntheticpeptidecorrespondingtotheC-terminusofratMAPKinase2/Erk2. |
Host | Rabbit |
Specificity | AntibodyrecognizesMAPK1/Erk1andMAPK2/Erk2 |
Isotype | IgG |
SpeciesReactivity | |
SpeciesReactivityNote | TestedandpassedonHuman.Unconjugatedversion(Cat.No.06-182)isknowntoreactwithAvian,Mouse,Rat,Sheep,Xenopus,Echinoderms.
|
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene. |
GeneSymbol | - MAPK1
- p38
- ERK
- P42MAPK
- ERK2
- p40
- PRKM1
- p41mapk
- PRKM2
- MAPK2
- p42-MAPK
- p41
- ERK-2
- ERT1
|
PurificationMethod | AntigenAffinity |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
COFACTOR:Magnesium(Bysimilarity).
SIZE:360aminoacids;41390Da
SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain. |
MolecularWeight | 41.4kDaCalculated |