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Abnova/ALPL FISH Probe/1kit/FA0022
  • Abnova/ALPL FISH Probe/1kit/FA0022

Abnova/ALPL FISH Probe/1kit/FA0022

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貨號(hào): FA0022
品牌: Abnova
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  • 詳情
  • 使用說(shuō)明
  • 常見(jiàn)問(wèn)題
      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 250 uL
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Gene Information
      • Entrez GeneID:
      • 249
      • Gene Name:
      • ALPL
      • Gene Alias:
      • AP-TNAP,FLJ40094,FLJ93059,HOPS,MGC161443,MGC167935,TNAP,TNSALP
      • Gene Description:
      • alkaline phosphatase, liver/bone/kidney
      • Omim ID:
      • 146300, 171760, 241500, 241510
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq
      • Other Designations:
      • OTTHUMP00000002971,OTTHUMP00000002972,alkaline phosphatase, tissue-nonspecific isozyme,alkaline phosphomonoesterase,glycerophosphatase,liver/bone/kidney-type alkaline phosphatase,tissue non-specific alkaline phosphatase,tissue-nonspecific ALP
      • Gene Pathway
      • Folate biosynthesis
      • gamma-Hexachlorocyclohexane degradation
      • Metabolic pathways
      • Related Disease
      • Alzheimer Disease
      • Alzheimer disease
      • Cardiovascular Diseases
      • Chondrocalcinosis
      • Diabetes Complications
      • Fractures, Bone
      • Genetic Predisposition to Disease
      • Hypertension
      • Hypophosphatasia
      • Kidney Failure, Chronic
      • Metabolic Syndrome X
      • Neoplasms
      • Osteoporosis
      • Osteoporosis, Postmenopausal
      • Spondylitis, Ankylosing
      • Tobacco Use Disorder
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