當(dāng)前位置 ： Abnova >>> Abnova/CDK4/CEN12 CISH Probe/1kit/CG0003
Abnova/CDK4/CEN12 CISH Probe/1kit/CG0003
  • Abnova/CDK4/CEN12 CISH Probe/1kit/CG0003

Abnova/CDK4/CEN12 CISH Probe/1kit/CG0003

價(jià)格: 試用 市場(chǎng)價(jià): 0.00
貨號(hào): CG0003
品牌: Abnova
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產(chǎn)品：無質(zhì)量問題不接受退換貨，下單前請(qǐng)仔細(xì)核對(duì)信息。
下單后請(qǐng)及時(shí)聯(lián)系客服核對(duì)商品價(jià)格，訂單生效后再付款。
資深產(chǎn)品顧問
咨詢顧問

全國免費(fèi)服務(wù)熱線

4000-520-616

  • 自營商城 一站式服務(wù)
  • 廠家直采 剔除溢價(jià)
  • 品質(zhì)甄選 正品保證
  • 嚴(yán)控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • CDK4/CEN12 CISH Probe is designed for the qualitative detection of human CDK4 gene amplifications as well as the detection of chromosome 12 alpha satellites in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
      • Recommend Usage:
      • The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
      • Supplied Product:
      • Reagent Provided:This Probe is composed of:1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 12q13.3-q14.1* (chr12:58,004,553-58,313,271) harboring the CDK4 gene region.2. Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 12p11.1-q11 specific for the alpha satellite centromeric region D12Z3 of chromosome 12. 3. Formamide based hybridization buffer.*according to Human Genome Assembly GRCh37/hg19
      • Storage Instruction:
      • Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
      • Note:
      • The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Interpretation of results:Using the CISH Implementation Kit 2 (Cat # KA5366), hybridization signals of Digoxigenin-labeled polynucleotides appear as dark green colored distinct dots (CDKN2A gene region), and Dinitrophenyl-labeled polynucleotides appear as bright red colored distinct dots (CEN 9).Normal situation: In interphases of normal cells or cells without a deletion involving the CDKN2A gene region, two distinct dot-shaped green and two distinct dot-shaped red signals appear.Aberrant situation: In a cell with deletion affecting the CDKN2A gene region, a reduced number of green signals will be observed. Deletions affecting only parts of the CDKN2A gene region might result in normal signal pattern with green signals of reduced size.Overlapping signals may appear as brown signals. Other signal patterns than those described above may be observed in some abnormal samples. These unexpected signal patterns should be further investigated.
      • Probe Position:
      • Regulatory Status:
      • For research use only (RUO)
      • Interpretation of Result:
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Chromogenic In Situ Hybridization (FFPE Tissue)
      • Chromogenic <i>In Situ</i> Hybridization (FFPE Tissue)
      • Liposarcoma tissue section with CDK4 amplification as indicated by large green clusters.
      • Application Image
      • Chromogenic In Situ Hybridization (FFPE Tissue)
      • Chromogenic <i>In Situ</i> Hybridization (FFPE Tissue)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 1019
      • Gene Name:
      • CDK4
      • Gene Alias:
      • CMM3,MGC14458,PSK-J3
      • Gene Description:
      • cyclin-dependent kinase 4
      • Omim ID:
      • 123829, 609048
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq
      • Other Designations:
      • cell division kinase 4,melanoma cutaneous malignant, 3
      • Gene Pathway
      • Bladder cancer
      • Cell cycle
      • Chronic myeloid leukemia
      • Glioma
      • Melanoma
      • Non-small cell lung cancer
      • p53 signaling pathway
      • Pancreatic cancer
      • Pathways in cancer
      • Small cell lung cancer
      • T cell receptor signaling pathway
      • Tight junction
      • Related Disease
      • Adenocarcinoma
      • Birth Weight
      • Brain Neoplasms
      • Breast cancer
      • Breast Neoplasms
      • Cardiovascular Diseases
      • Diabetes Mellitus, Type 2
      • Edema
      • Esophageal Neoplasms
      • Genetic Predisposition to Disease
      • Glioblastoma
      • Head and Neck Neoplasms
      • Kidney Failure, Chronic
      • Leukemia, Lymphocytic, Acute, L1
      • Lung Neoplasms
      • Lymphoma, Non-Hodgkin
      • Malignant melanoma
      • Melanoma
      • Mouth Neoplasms
          • ... see more
    售后保障
    螞蟻淘生物188，秉承螞蟻淘一貫的嚴(yán)謹(jǐn)態(tài)度，由螞蟻淘公司專業(yè)人員負(fù)責(zé)品控、采購、物流、銷售、售后，保障正品優(yōu)質(zhì)。以“快速好省，為科研提供好產(chǎn)品、好價(jià)格”為理念，直接鏈接原廠家，從全國各地原制造商嚴(yán)格挑選188款科研精品，剔除品牌溢價(jià)，188生物新電商，把好的產(chǎn)品帶給科研！? 力求給你最優(yōu)質(zhì)的商品。
  • Q：生物188產(chǎn)品正品保障嗎？
    A：生物188質(zhì)量把控人員具有十年的從業(yè)經(jīng)驗(yàn)，在業(yè)界享有良好的口碑；自營商城，直接從廠家采購， 自己的團(tuán)隊(duì)負(fù)責(zé)國際物流和清關(guān)，中間沒有第三方，所有流程嚴(yán)格把控，100%保證正品，假一罰十。

    Q：下單后可以修改訂單嗎？
    A：下單后的商品付款之前可以修改；訂單付款成功，需要聯(lián)系我們客服進(jìn)行修改；客服電話：4000-520-616

    Q：可以開發(fā)票嗎？
    A：本網(wǎng)站所售商品都是正規(guī)清關(guān)，均開具16%正規(guī)發(fā)票，發(fā)票金額含配送費(fèi)金額，另有說明的除外。

    Q：商品幾天可以發(fā)貨？
    A：生物188商品，全部現(xiàn)貨銷售，付款后即可發(fā)貨,一般一周內(nèi)送達(dá)！

    Q：如何聯(lián)系商家？
    A：有任何問題夠可以電話咨詢我們，全國24小時(shí)免費(fèi)服務(wù)熱線：4000-520-616 或聯(lián)系我們的在線客服QQ：1570468124

    Q：收到的商品少了/發(fā)錯(cuò)了怎么辦？
    A：同個(gè)訂單購買多個(gè)商品可能會(huì)分為一個(gè)以上包裹發(fā)出，可能不會(huì)同時(shí)送達(dá)，建議查看訂單詳情是否是 部分發(fā)貨狀態(tài)；如未收到，可聯(lián)系在線客服或者致電4000-520-616。

    Q：退換貨/維修需要多長時(shí)間？
    A：一般情況下，退貨處理周期為客戶收到產(chǎn)品一個(gè)月內(nèi)（以快遞公司顯示簽收時(shí)間為準(zhǔn)），包裝規(guī)格、 數(shù)量、品種不符，外觀毀損、短缺或缺陷，請(qǐng)?jiān)谑盏截?4小時(shí)內(nèi)申請(qǐng)退換貨；特殊商品以合同條款為準(zhǔn)。

何為188

極簡而嚴(yán)謹(jǐn)，我們僅銷售188款生物醫(yī)學(xué)科研用品，款款都是爆款；因?yàn)樯偎跃劢?，聚焦甄選每一款產(chǎn)品，聚焦服務(wù)每一位客戶!

關(guān)注我們 :

點(diǎn)擊QQ聯(lián)系我們
生物188微信

關(guān)注188微信公眾號(hào)

獲取最新優(yōu)惠活動(dòng)通知

  • 品質(zhì)甄選，正品保證

  • 自營電商，廠家直采

  • 極簡主義，188精品