Immunogen | 12aminoacidpeptideoftheC-terminusofhGLUT-1{LFHPLGADSQV}conjugatedtoKLH |
Epitope | C-terminus |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Specificforhumanglucosetransporter1frommuscleandadiposetissue.Doesnotcross-reactwithGLUT-4.Themolecularweightoftheglucosetransporterprecipitatedbytheserumisapproximately46kDa. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Glucosetransportersareintegralmembraneglycoproteinsinvolvedintransportingglucoseintomostcells.GLUT1isamajorglucosetransporterinthemammalianblood-brainbarrier.Itispresentathighlevelsinprimateerythrocytesandbrainendothelialcells.[suppliedbyOMIM] |
GeneSymbol | - SLC2A1
- GLUT-1
- MGC141896
- GLUT1
- MGC141895
- GLUT
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P11166#Facilitativeglucosetransporter.ThisisoformmayberesponsIBLeforconstitutiveorbasalglucoseuptake.Hasaverybroadsubstratespecificity;cantransportawiderangeofaldosesincludingbothpentosesandhexoses. SIZE:492aminoacids;54084Da SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein(Bysimilarity).Melanosome.Note=Localizesprimarilyatthecellsurface(Bysimilarity).IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV. TISSUESPECIFICITY:Expressedatvariablelevelsinmanyhumantissues. PTM:PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:SwissProt:P11166#DefectsinSLC2A1arethecauseofautosomaldominantGLUT1deficiencysyndrome[MIM:606777].Thisdiseasecausesadefectinglucosetransportacrosstheblood-brainbarrier.Itischaracterizedbyinfantileseizures,delayeddevelopment,andacquiredmicrocephaly. SIMILARITY:SwissProt:P11166##Belongstothemajorfacilitatorsuperfamily.Sugartransporter(TC2.A.1.1)family.Glucosetransportersubfamily. |
MolecularWeight | 46kDa |