Immunogen | Syntheticpeptidecorrespondstosequencesurroundingthephosphoserine515siteofratMunc-18. |
Host | Rabbit |
Specificity | Munc-18,phosphoSerine515.Theantibodyrecognizesaproteinof~65kDacorrespondingtoMunc-18,phosphoSerine515inlysatesfromratcortex.Immunolabelingisblockedbythephosphopeptideusedastheimmunogenbutnotthecorrespondingnon-phosphopeptide. |
SpeciesReactivity | |
SpeciesReactivityNote | Theimmunogenhas100%homologywithhuman,mouse,non-humanprimates,bovine,canine,chickenandXenopus. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol | |
Modifications | |
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P61765#Mayparticipateintheregulationofsynapticvesicledockingandfusion,possIBLythroughinteractionwithGTP-bindingproteins.Essentialforneurotransmissionandbindssyntaxin,acomponentofthesynapticvesiclefusionmachineryprobablyina1:1ratio.Caninteractwithsyntaxins1,2,and3butnotsyntaxin4.Mayplayaroleindeterminingthespecificityofintracellularfusionreactions. SIZE:594aminoacids;67569Da SUBCELLULARLOCATION:Cytoplasm.Membrane;Peripheralmembraneprotein. TISSUESPECIFICITY:Brainandspinalcord.Highlyenrichedinaxons. SIMILARITY:SwissProt:P61765##BelongstotheSTXBP/unc-18/SEC1family. |