Immunogen | Syntheticpeptidecorrespondingtoaminoacids108-127ofsolublecytoplasmichumanPGP9.5. |
Host | Rabbit |
Specificity | ProteinGeneProduct9.5(PGP9.5). |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | UCHL1isamemberofagenefamilywhoseproductshydrolyzesmallC-terminaladductsofubiquitintogeneratetheubiquitinmonomer.ExpressionofUCHL1ishighlyspecifictoneuronsandtocellsofthediffuseneuroendocrinesystemandtheirtumors.Itispresentinallneurons(Doranetal.,1983[PubMed6343558]).[suppliedbyOMIM] |
GeneSymbol | - UCHL1
- PARK5
- UCH-L1
- Uch-L1
- PGP9.5
- EC3.4.19.12
- EC6.-.-.-
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P09936#Ubiquitin-proteinhydrolaseinvolvedbothintheprocessingofubiquitinprecursorsandofubiquitinatedproteins.ThisenzymeisathiolproteasethatrecognizesandhydrolyzesapeptidebondattheC-terminalglycineofubiquitin.Alsobindstofreemonoubiquitinandmaypreventitsdegradationinlysosomes.ThehomodimermayhaveATP-independentubiquitinligaseactivity. SIZE:223aminoacids;24824Da SUBUNIT:Homodimer.InteractswithSNCA(Bysimilarity).InteractswithCOPS5. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Foundinneuronalcellbodiesandprocessesthroughouttheneocortex(atproteinlevel).Expressedinneuronsandcellsofthediffuseneuroendocrinesystemandtheirtumors.Weaklyexpressedinovary. PTM:O-glycosylated(Bysimilarity). DISEASE:SwissProt:P09936#OxidationofMet-1,Met-6,Met-12,Met-124andMet-179tomethioninesulfoxide,andoxidationofCys-220tocysteinesulfonicacidhavebeenobservedinbrainsfromAlzheimerdisease(AD)andParkinsondisease(PD)patients.InAD,UCHL1wasfoundtobeassociatedwithneurofibrillarytangles. SIMILARITY:SwissProt:P09936##BelongstothepeptidaseC12family. MISCELLANEOUS:IncontrasttoUCHL3,doesnothydrolyzeapeptidebondattheC-terminalglycineofNEDD8. |