Immunogen | RecombinantratGAP-43(completesequence). |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesGrowthAssociatedProtein-43(GAP-43). |
SpeciesReactivity | - Human
- Mouse
- Rat
- Chicken
- Bovine
|
SpeciesReactivityNote | Reactstoahighdegreewithmouse.Reactstoalesserdegreewithrat,human,bovineandchicken.Otherspecieshavenotbeentested. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgenehasbeentermeda"growth"or"plasticity"proteinbecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandaxonalregeneration.Thisencodedproteinisconsideredacrucialcomponentofaneffectiveregenerativeresponseinthenervoussystem. |
GeneSymbol | |
PurificationMethod | AmmoniumSulfatePrecipitation |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P17677#Thisproteinisassociatedwithnervegrowth.Itisamajorcomponentofthemotilegrowthconesthatformthetipsofelongatingaxons. SIZE:238aminoacids;24803Da SUBUNIT:BindscalmodulinwithagreateraffinityintheabsenceofCa(2+)thaninitspresence(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellprojection,growthconemembrane;Peripheralmembraneprotein;Cytoplasmicside.Celljunction,synapse.Note=Cytoplasmicsurfaceofgrowthconeandsynapticplasmamembranes. PTM:PhosphorylationofthisproteinbyaproteinkinaseCisspecificallycorrelatedwithcertainformsofsynapticplasticity. SIMILARITY:SwissProt:P17677##Belongstotheneuromodulinfamily.&Contains1IQdomain. |
MolecularWeight | 23.6kDa |