Immunogen | Syntheticpeptidecorrespondingtoaminoacidresiduessurroundingandincludingtyrosine731(phosphorylated)ofhumanVE-Cadherin.Theimmunogensequenceis100%identicalinchimpanzee,mouse,rat,chicken,zebrafish,cow,dogand91%identicalinpigVE-cadherin. |
Epitope | Tyr731 |
Host | Rabbit |
Specificity | Theantibodydetectsa120kDaproteincorrespondingtoVE-cadherin. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
GeneSymbol | |
Modifications | |
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains. |
MolecularWeight | 120kDa |