Immunogen | Syntheticpeptide |
Host | Rabbit |
Specificity | NeuroD1(Neurogenicdifferentiationfactor1).ByWesternblottheantibodyrecognizesabandat~45kDaonhuman,ratandmousebrainlysate. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneencodesamemberoftheNeuroDfamilyofbasichelix-loop-helix(bHLH)transcriptionfactors.TheproteinformsheterodimerswithotherbHLHproteinsandactivatestranscriptionofgenesthatcontainaspecificDNAsequenceknownastheE-box.Itregulatesexpressionoftheinsulingene,andmutationsinthisgeneresultintypeIIdiabetesmellitus. |
GeneSymbol | - NEUROD1
- NeuroD1
- NeuroD
- BETA2
- BHF-1
- NEUROD
- NIDDM
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q13562#Differentiationfactorrequiredfordendritemorphogenesisandmaintenanceinthecerebellarcortex.Transcriptionalactivator.BindstotheinsulingeneE-box. SIZE:356aminoacids;39890Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.HeterodimerwithTCF3/E47.InteractswithRREB1. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Nucleus(Bysimilarity). PTM:Phosphorylated.Inisletcells,phosphorylatedonSer-274uponglucosestimulation;whichmayberequiredfornuclearlocalization.Inactivatedneurons,phosphorylatedonSer-335;whichpromotesdendriticgrowth(Bysimilarity). DISEASE:SwissProt:Q13562#DefectsinNEUROD1arethecauseofmaturityonsetdiabetesoftheyoungtype6(MODY6)[MIM:606394].MODY[MIM:606391]ischaracterizedbyanautosomaldominantmodeofinheritance,onsetduringyoungadulthoodandaprimarydefectininsulinsecretion. SIMILARITY:SwissProt:Q13562##Contains1basichelix-loop-helix(bHLH)domain. |