The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Product NameBAX Polyclonal AntibodyBax Rabbit mAbBCL2L4; BAX
Host Species Rabbit
Purification Method Affinity purification
IsotypeIgG
Storage/HandlingStore at -20℃.Avoid freeze / thaw cycles.
Storage BufferPBS with 0.02% sodium azide, 50%glycerol, pH7.3.
Immunogen Information
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human BAX (NP_620116.1).
Sequence MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF
Gene ID: 581
Swiss Protein: Q07812
Calculated MW: 4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa
Observed MW: 23 kDa
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