Synonym:D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide,D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol,D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide,ChloromycetinCASNumber56-75-7
LinearFormulaCl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
MolecularWeight323.13
BeilsteinRegistryNumber2225532
MDLnumberMFCD00078159
PubChemSubstanceID329749306
Properties:
RelatedCategories | AnalyticalStandards,Analytical/Chromatography,Pharmacopeia&MetrologicalInstitutesStandards,USPStandards,USPStandardsC-D |
Description:
Biochem/physiolActions
ModeofAction:Chloramphenicolinhibitsbacterialproteinsynthesisbyblockingthepeptidyltransferasestepbybindingtothe50SribosomalsubunitandpreventingattachmentofaminoacyltRNAtotheribosome.Italsoinhibitsmitochondrialandchloroplastproteinsynthesisandribosomalformationof(p)ppGpp,de-pressingrRNAtranscription.
ModeofResistance:Useofchloramphenicolacetyltransferasewillacetylatetheproductandinactivateit.
AntimicrobialSpectrum:Thisisabroadspectrumantibioticagainstgram-positiveandgram-negativebacteria,andisusedmainlyforophthalmicandveterinarypurposes.
Generaldescription
ThisproductisprovidedasdeliveredandspecifiedbytheissuingPharmacopoeia.Allinformationprovidedinsupportofthisproduct,includingSDSandanyproductinformationleafletshavebeendevelopedandissuedundertheAuthorityoftheissuingPh
OtherNotes
Salesrestrictionsmayapply.
USPissuedSDScanbefoundhere.
Safety:
Symbol
GHS08
Precautionarystatements
P201-P280-P308+P313
RIDADR
NONHforallmodesoftransport