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Millipore/07-770 | Anti-acetyl-Histone H2A.Z (Lys8) Antibody | 07-770/07-770/100 µg
  • Millipore/07-770 | Anti-acetyl-Histone H2A.Z (Lys8) Antibody | 07-770/07-770/100 µg

Millipore/07-770 | Anti-acetyl-Histone H2A.Z (Lys8) Antibody | 07-770/07-770/100 µg

價格: ￥5304.00 市場價: 8840.00
貨號: 07-770
品牌: Millipore
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    • Description
      CatalogueNumber07-770
      DescriptionAnti-acetyl-HistoneH2A.Z(Lys8)Antibody|07-770
      AlternateNames
      • H2Ahistonefamily,memberZ
      • H2AZhistone
      • histoneH2A.Z
      • Htz1
      BackgroundInformationH2A.Z,alsoknownasH2AFZ,isavariantofhistoneH2Avariantthatishighlyconservedfromyeasttohumans.Likeotherhistonevariants,H2A.Zisencodedbyauniquegene,resultinginaslightlydivergenttypeofH2Awithspecializedfunctions.H2A.ZisinvolvedinchromatincompactionbystABIlizingthehistoneoctamerwithinthenucleosome.Itpromotesgeneexpressionthroughthecreationofanopendomainofchromatinthatismoreeasilytranscribed.H2A.Zisnonrandomlydistributedthroughoutthegenome,targetedprimarilytopericentricheterochromatin,butexcludedfromtheinactiveXchromosomeandthenucleolus.H2A.Zisassociatedwithbotheuchromatinandfacultativeheterochromatin.DNAmethylationcaninfluencechromatinstructureandeffectgenesilencingbyexcludingH2A.Z,andlikewise,H2A.ZprotectsgenesfromDNAmethylation.Thus,H2A.Zplaysaroleinregulatingheterochromatinsilencingandisinvolvedintranscriptionalcontrol.
      ProductInformation
      FormatAffinityPurified
      Control
      • Yeastwholecellextract
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternBlot(Snapi.d.)Analysis:4μg/mLfromarepresentativelotdetectedHistoneH2A.Zon10μgofyeastwholecellextract.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtoyeastHistoneH2A.ZacetylatedatLys8.
      EpitopeHistoneH2A.ZacetylatedLys8
      Concentration0.5mg/mL
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneH2A.ZwhenacetylatedatLys8.
      SpeciesReactivity
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • H2A.z
      • H2A/z
      • H2AZ
      • H2AFZ
      Modifications
      • Acetylation
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:VarianthistoneH2AwhichcanreplaceH2Ainsomenucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Thisvariantisenrichedatpromoters,itmaykeeptheminarepressedstateuntiltheappropriateactivationsignalisreceived.Neartelomeres,itmaycounteractgenesilencingcausedbythespreadofheterochromatinproteins.RequiredfortheRNApolymeraseIIandSPT15/TBPrecruitmenttothetargetgenes.Involvedinchromosomestability.

      SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.H2AoritsvariantH2A.ZformsanheterodimerwithH2B.H2A.ZassociateswiththeVPS72/SWC2subunitoftheSWR1chromatinremodelingcomplex.InteractsalsowithRBP1/DNA-directedRNApolymeraseIIlargestsubunit.InteractswithNAP1.

      SUBCELLULARLOCATION:Nucleus

      PTM:AcetylatedbyESA1,acomponentoftheNuA4histoneacetyltransferase(HAT)complex,and/orbyGCN5,acomponentoftheSAGAcomplex,toformH2A.ZK3Ac,H2A.ZK8Ac,H2A.ZK10AcandH2A.ZK14Aconcedepositedintochromatin.Acetylationisrequiredforfunctionattelomeres.H2A.ZK14Acisacetylatedatthepromotersofactivegenes.

      MISCELLANEOUS:Presentwith2840molecules/cellinlogphaseSDmedium.

      IncontrasttoH2A1andH2A2,appearstobeweaklyornotsumoylated.

      SEQUENCESIMILARITIES:BelongstothehistoneH2Afamily.

      CAUTION:Toensureconsistencybetweenhistoneentries,wefollowthe"Brno"nomenclatureforhistonemodifications,withpositionsreferingtothoseusedintheliteratureforthe"closest"modelorganism.DuetoslightvariationsinhistonesequencesbetweenorganismsandtothepresenceofinitiatormethionineinUniProtKB/Swiss-Protsequences,theactualpositionsofmodifiedaminoacidsinthesequencegenerallydiffer.Inthisentrythefollowingconventionsareused:H2A.ZK3ac=acetylatedLys-4;H2A.ZK8ac=acetylatedLys-9;H2A.ZK10ac=acetylatedLys-11;H2A.ZK14ac=acetylatedLys-15.
      MolecularWeight~16kDaobserved.Slightlycross-reactingband~14kDa(HistoneH4)withTBS-T(01%).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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