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Millipore/07-1584 | Anti-dimethyl Histone H4 (Lys20) Antibody/07-1584/100 µg
  • Millipore/07-1584 | Anti-dimethyl Histone H4 (Lys20) Antibody/07-1584/100 µg

Millipore/07-1584 | Anti-dimethyl Histone H4 (Lys20) Antibody/07-1584/100 µg

價格: ￥4680.00 市場價: 7800.00
貨號: 07-1584
品牌: Millipore
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    • Description
      CatalogueNumber07-1584
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-dimethylHistoneH4(Lys20)Antibody
      AlternateNames
      • H4K20me2
      • HistoneH4(dimethylK20)
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).Inmammals,H4K20methylationisoneofthemostcommonchromatinmodificationsandithasbeenimplicatedinvariousBIOLOGicalprocesses,includingheterochromatinformation,telomerefunction,imprinting,Xinactivation,DNAdamagerepairandcancerprogression.H4K20me2isthemostabundanthistonemodificationwithmorethat80%ofallhistoneH4moleculescarryingthismark.TheSuv4-20henzymesarethetwomajorhistonemethyltransferasestoinduceH4K20me2andme3states.
      ProductInformation
      FormatPurified
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.
      Applications
      ApplicationAnti-dimethylHistoneH4(Lys20)AntibodyisaRabbitPolyclonalAntibodyfordetectionofdimethylHistoneH4(Lys20)alsoknownasH4K20me2,HistoneH4(dimethylK20)&hasbeenvalidatedinWB.
      KeyApplications
      • WesternBlotting
      BiologicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecontainingthesequence(AKRHR[dimethyl-K]VLRD-C),correspondingtothesequencesurroundingacetylatedlysine20ofhumanhistoneH4.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizeshistoneH4acetylatedonLys20,Mr~10kDa.
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteBroadspeciescross-reactivityexpectedduetosequencehomology
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.
      Modifications
      • Methylation
      UniProtNumber
      UniProtSummaryFUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      INTERACTION:
      Q13547:HDAC1;NbExp=1;IntAct=EBI-302023,EBI-301834;
      P56524:HDAC4;NbExp=1;IntAct=EBI-302023,EBI-308629;
      Q9UQL6:HDAC5;NbExp=1;IntAct=EBI-302023,EBI-715576;
      Q9UBN7:HDAC6;NbExp=1;IntAct=EBI-302023,EBI-301697;
      Q9Y468:L3MBTL;NbExp=2;IntAct=EBI-302023,EBI-1265089;
      Q9SU94:PRMT1.1(xeno);NbExp=1;IntAct=EBI-302023,EBI-1382731;
      O82210:PRMT1.2(xeno);NbExp=1;IntAct=EBI-302023,EBI-1382526;
      Q9NQR1:SETD8;NbExp=4;IntAct=EBI-302023,EBI-1268946;

      SUBCELLULARLOCATION:Nucleus.
      PTM:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin.
      PTM:CitrullinationatArg-4byPADI4impairsmethylation.
      PTM:MonomethylationatArg-4byPRMT1favorsacetylationatLys-9andLys-13.DemethylationisperformedbyJMJD6.
      PTM:Monomethylated,dimethylatedortrimethylatedatLys-21.MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing.
      PTM:UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      PTM:Sumoylated,whichisassociatedwithtranscriptionalrepression.
      SIMILARITY:BelongstothehistoneH4family.
      MolecularWeight~10kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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