BackgroundInformation | Rad51issimilartoRecA,bothbiochemicallyandstructurally.Itpromoteshomologouspairingandstrandexchangewithinaregularnucleoproteinfilament.Inyeast,theRad51familyofrelatedproteinsalsoincludesRad55,Rad57,andDmc1.Inmammaliancells,sevengenesinthisfamilyhavebeenidentified(HsRAD51,XRCC2,XRCC3,RAD51B/hREC2andHsDMC1,RAD51C,andRAD51D).RecentstudiessuggestedthatRad51isinvolvednotonlyinhomologousrecombinationbutalsoincellproliferationregulation. |