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Millipore/05-516 | Anti-Ras Antibody, clone RAS10/05-516/100 µg
  • Millipore/05-516 | Anti-Ras Antibody, clone RAS10/05-516/100 µg

Millipore/05-516 | Anti-Ras Antibody, clone RAS10/05-516/100 µg

價格: ￥4188.00 市場價: 6980.00
貨號: 05-516
品牌: Millipore
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    • Description
      CatalogueNumber05-516
      ReplacesCBL751
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-RasAntibody,cloneRAS10
      AlternateNames
      • GTP-andGDP-bindingpeptideB
      • GTPaseHras
      • Ha-Ras1proto-oncoprotein
      • RasfamilysmallGTPbindingproteinH-Ras
      • Transformingproteinp2
      • c-has/basp21protein
      • c-ras-Ki-2activatedoncogene
      • p19H-RasIDXprotein
      • transformationgene:oncogeneHAMSV
      • v-Ha-rasHarveyratsarcomaviraloncogenehomolog
      BackgroundInformationThetumoroncoproteinsHRas,KRas,andNRasareratedasRasprotoncogenes.PointmutationswithinRasgenesarefrequentlydetectedinhumanmalignanciesandinexperimentallyinducedtumorsinanimals.
      ProductInformation
      FormatPurified
      Control
      • IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Use20μgperlaneforminigels
      PresentationPurifiedmousemonoclonalIgG2akinbuffercontainingPBS,pH7.4,with0.05%sodiumazideand30%glycerol.Liquidat-20°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationDetectRasusingthisAnti-RasAntibody,cloneRAS10validatedforuseinELISA,FC,IC,IH,IP&WB.
      KeyApplications
      • ELISA
      • FlowCytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      1-4μgofthisantibodyhasbeenreportedtoimmunoprecipitateRas.

      Immunocytochemistry:
      2.5μg/mLofthisantibodyhasbeenreportedtoshowpositiveimmunostainingforRasinSW480andY1cells.

      Immunohistochemistry:
      ThisantibodyhasbeenreportedtodetectRasinfrozenandparaffinembeddedbreastcarcinomasections.
      BIOLOGicalInformation
      ImmunogenPurifiedrecombinantRas.CloneRAS10.
      CloneRAS10
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesp21H-,K-andN-Ras.
      IsotypeIgG2aκ
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      SpeciesReactivityNoteProventoreactwithhuman,mouseandrat.Otherspeciesunknown.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryMembersoftheRASsuperfamilyofGTP-bindingproteins,whichincludesMRAS,aremembrane-anchored,intracellularsignaltransducersresponsIBLeforavarietyofnormalcellularfunctions.Theyareoncogenicallyactivatedinasignificantfractionoftumors.[suppliedbyOMIM]
      GeneSymbol
      • K-Ras
      • Ki-Ras
      • K-Ras2
      • Kras-2
      • p21B
      • KRAS
      • RASK2
      • HRAS
      • HA_RAS
      • N-RAS
      • H-RAS
      • NRAS
      • NRAS1
      • ALPS4
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity.
      Enzymeregulation:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP).
      SIZE:189aminoacids;21,656Da
      SUBUNIT:InteractswithPHLPP(Bysimilarity).
      SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside.
      Involvementindisease:
      DefectsinKRASareacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment.

      DefectsinKRASareacauseofjuvenilemyelomonocyticleukemia(JMML)[MIM:607785].JMMLisapediatricmyelodysplasticsyndromethatconstitutesapproximately30%ofchildhoodcasesofmyelodysplasticsyndrome(MDS)and2%ofleukemia.ItischaracterizedbyleukocytosiswithtissueinfiltrationandinvitrohypersensitivityofmyeloidProgenitorstogranulocyte-macrophagecolonystimulatingfactor.

      DefectsinKRASarethecauseofNoonansyndrome3(NS3)[MIM:609942].Noonansyndrome(NS)[MIM:163950]isadisordercharacterizedbydysmorphicfacialfeatures,shortstature,hypertelorism,cardiacanomalies,deafness,motordelay,andableedingdiathesis.Itisageneticallyheterogeneousandrelativelycommonsyndrome,withanestimatedincidenceof1in1000-2500livebirths.Rarely,NSisassociatedwithjuvenilemyelomonocyticleukemia(JMML).NS3inheritanceisautosomaldominant.

      DefectsinKRASareacauseofcardiofaciocutaneoussyndrome(CFCsyndrome)[MIM:115150];alsoknownascardio-facio-cutaneoussyndrome.CFCsyndromeischaracterizedbyadistinctivefacialappearance,heartdefectsandmentalretardation.Heartdefectsincludepulmonicstenosis,atrialseptaldefectsandhypertrophiccardiomyopathy.Someaffectedindividualspresentwithectodermalabnormalitiessuchassparse,friablehair,hyperkeratoticskinlesionsandageneralizedichthyosis-likecondition.TypicalfacialfeaturesaresimilartoNoonansyndrome.Theyincludehighforeheadwithbitemporalconstriction,hypoplasticsupraorbitalridges,downslantingpalpebralfissures,adepressednasalbridge,andposteriorlyangulatedearswithprominenthelices.TheinheritanceofCFCsyndromeisautosomaldominant.

      KRASmutationsareinvolvedincancerdevelopment.
      MolecularWeight21kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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