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Millipore/05-157 | Anti-MAP Kinase 2/Erk2 Antibody, clone 1B3B9/05-157/200 µg
  • Millipore/05-157 | Anti-MAP Kinase 2/Erk2 Antibody, clone 1B3B9/05-157/200 µg

Millipore/05-157 | Anti-MAP Kinase 2/Erk2 Antibody, clone 1B3B9/05-157/200 µg

價(jià)格: ￥3948.00 市場價(jià): 6580.00
貨號: 05-157
品牌: Millipore
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    • Description
      CatalogueNumber05-157
      Replaces04-349
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-MAPKinase2/Erk2Antibody,clone1B3B9
      AlternateNames
      • Extracellularsignal-regulatedkinase2
      • MAPkinase2
      • MAPK2
      • Mitogen-activatedproteinkinase2
      • extracellularsignal-regulatedkinase-2
      • mitogen-activatedproteinkinase1
      • proteintyrosinekinaseERK2.
      BackgroundInformationERK2isactivatedbyMEK2,whichphosphorylatesneighboringthreonine183andtyrosine185residues.ERK2isaserine/threoninekinasethatphosphorylatesMAP2andmyelinbasicprotein.ThiskinaseisanimportantproximalcomponentoftheMAPkinasepathwayinvolvedintranseittingthesignalsfromgrowthfactors,neurotransmittersandhormonesatthecellsurfacetothetranscriptionaleventsinthenucleus.
      ProductInformation
      FormatPurified
      Control
      • A431,HeLaandNIH/3T3celllysates
        IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedmousemonoclonalIgG2ainbuffercontainingPBSwith0.05%sodiumazide.Storefrozenat-20°C,avoidfreezethawcycles.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.

      HandlingRecommendations:
      Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-MAPKinase2/Erk2Antibody,clone1B3B9isanantibodyagainstMAPKinase2/Erk2foruseinIP&WB.
      KeyApplications
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      4μgofapreviouslotimmunoprecipitatedMAPKinase2/Erk2fromaRIPAlysatefrommouse3T3cells.Boilthecelllysateandletcoolbeforeaddingtheantibody,asthisantibodyonlybindstodenaturedMAPKinase.
      BIOLOGicalInformation
      ImmunogenHPLCpurifiedmurinerecombinantMAPKinase.Clone1B3B9
      Clone1B3B9
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesMAPkinaseencodedbythemapkgene,Mr42kDa.
      IsotypeIgG2a
      SpeciesReactivity
      • Avian
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteProventoreactwithHuman,Mouse,andRat.
      Otherspeciescrossreactivityisunknown.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
      GeneSymbol
      • MAPK1
      • p38
      • ERK
      • P42MAPK
      • ERK2
      • p40
      • PRKM1
      • p41mapk
      • PRKM2
      • MAPK2
      • p42-MAPK
      • p41
      • ERK-2
      • ERT1
      PurificationMethodProteinGChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
      COFACTOR:Magnesium(Bysimilarity).
      SIZE:360aminoacids;41390Da
      SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
      DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain
      MolecularWeight42kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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