Immunogen | KLH-conjugatedsyntheticpeptidecomposedofresiduesattheN-terminusofhumanCaspase-7. |
Host | Rabbit |
Specificity | RecognizesaregioncomposedofresiduesattheN-terminusofhumanCaspase-7. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theprecursorofthiscaspaseiscleavedbycaspase3and10.Itisactivateduponcelldeathstimuliandinducesapoptosis.Alternativesplicingresultsinfourtranscriptvariants,encodingthreedistinctisoforms. |
GeneSymbol | - CASP7
- CASP-7
- ICE-LAP3
- CMH-1
- MCH3
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P55210#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Proteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Overexpressionpromotesprogrammedcelldeath. SIZE:303aminoacids;34277Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda11kDa(p11)subunit. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinlung,skeletalmuscle,liver,kidney,spleenandheart,andmoderatelyintestis.Noexpressioninthebrain. PTM:CleavagesbygranzymeBorcaspase-10generatethetwoactivesubunits.Propeptidedomainscanalsobecleavedefficientlybycaspase-3.Activeheterodimersbetweenthesmallsubunitofcaspase-7andthelargesubunitofcaspase-3,andviceversa,alsooccur. SIMILARITY:SwissProt:P55210##BelongstothepeptidaseC14family. |
MolecularWeight | 34kDa |