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Millipore/04-1054 | Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal/04-1054/100 µL
  • Millipore/04-1054 | Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal/04-1054/100 µL

Millipore/04-1054 | Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal/04-1054/100 µL

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貨號(hào): 04-1054
品牌: Millipore
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    • Description
      CatalogueNumber04-1054
      DescriptionAnti-S100-β(CT)Antibody,cloneEP1576Y,rabbitmonoclonal
      AlternateNames
      • S-100calcium-bindingprotein,betachain
      • S-100proteinbetachain
      • S-100proteinsubunitbeta
      • S100beta
      • S100calciumbindingproteinB
      • S100calciumbindingprotein,beta(neural)
      • S100calcium-bindingproteinB
      • S100calcium-bindingprotein,beta
      • S100calcium-bindingprotein,beta(neural)
      BackgroundInformationS-100proteinisamemberoftheEF-handcalcium-bindingproteinsuperfamilythatiswidelydistributedandconservedinthecentralnervoussystemofvertebrates.Theproteinexistsinbothheterodimericandhomodimericforms.ThetwosubunitsofS-100proteinaretheproductsofseparategenesthataredifferentiallyexpressedbyvariouscells.ThebetasubunitispresentinallS-100positivecellsandtumors.Incontrast,thealphasubunitisdetectableonlyinheart,skeletalmuscleandbrain.Inadditiontoitscalciumbindingproperties,S-100proteinhasahigh-affinitybindingsiteforzincandisinvolvedintheregulationofproteinphosphorylationinthebrain.Theproteinapparentlyplaysaroleincelldifferentiationandgrowth,cytoskeletalstructureandfunction,andhasbeenimplicatedinneuropathologicaldiseases.
      ProductInformation
      FormatUnpurified
      Control
      • A375celllysate
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectS100-β(C-term)usingthisAnti-S100-β(C-term)Antibody,cloneEP1576Y,RabbitvalidatedforuseinWB,IH(P)&IP.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      ApplicationNotesImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedS100-βinhumanmelanomatissue.
      ImmunoprecipitationAnalysis:A1:40dilutionfromapreviouslotwasusedinIP.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoresiduesontheC-terminusofhumanS100-β.
      EpitopeC-terminus
      CloneEP1576Y
      HostRabbit
      SpecificityThisantibodyrecognizesS100-βatandaroundtheC-terminus.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheS100familyofproteinscontaining2EF-handcalcium-bindingmotifs.S100proteinsarelocalizedinthecytoplasmand/ornucleusofawiderangeofcells,andinvolvedintheregulationofanumberofcellularprocessessuchascellcycleprogressionanddifferentiation.S100genesincludeatleast13memberswhicharelocatedasaclusteronchromosome1q21;however,thisgeneislocatedat21q22.3.ThisproteinmayfunctioninNeuriteextension,proliferationofmelanomacells,stimulationofCa2+fluxes,inhibitionofPKC-mediatedphosphorylation,astrocytosisandaxonalproliferation,andinhibitionofmicrotubuleassembly.Chromosomalrearrangementsandalteredexpressionofthisgenehavebeenimplicatedinseveralneurological,neoplastic,andothertypesofdiseases,includingAlzheimer"sdisease,Down"ssyndrome,epilepsy,amyotrophiclateralsclerosis,melanoma,andtypeIdiabetes.
      GeneSymbol
      • NEF
      • OTTHUMP00000174958
      • S100
      • S100beta
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Weaklybindscalciumbutbindszincverytightly-distinctbindingsiteswithdifferentaffinitiesexistforbothionsoneachmonomer.Physiologicalconcentrationsofpotassiumionantagonizethebindingofbothdivalentcations,especiallyaffectinghigh-affinitycalcium-bindingsites.BindstoandinitiatestheactivationofSTK38byreleasingautoinhibitoryintramolecularinteractionswithinthekinase.
      SUBUNITSTRUCTURE:Dimerofeithertwoalphachains,ortwobetachains,oronealphaandonebetachain.TheS100BdimerbindstwomoleculesofSTK38Bysimilarity.TheS100BdimerinteractswithtwomoleculesofCAPZA1.
      SUBCELLULARLOCATION:Cytoplasm.Nucleus.
      TISSUESPECIFICITY:Althoughpredominantamongthewater-solublebrainproteins,S100isalsofoundinavarietyofothertissues.
      MISCELLANEOUS:Inadditiontometal-ionbinding,thisproteinisinvolvedwiththeregulationofproteinphosphorylationinbraintissue.
      SEQUENCESIMILARITIES:BelongstotheS-101family.
      Contains2EF-handdomains.
      MolecularWeight~11kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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